The lungs are capable of repair but, in some people lung repair doesn’t happen properly either because of genetic mutations and/or exposure to repeated damaging exposures such as pollution or smoking. There are several common lung diseases where the gas exchange surface of the lungs (alveoli) becomes damaged including chronic obstructive pulmonary disease (COPD), adult respiratory distress syndrome (ARDS) and pneumonia. Also, premature babies often have fewer alveoli than a full-term baby because they have had less time in utero. This can lead to a disease called Bronchopulmonary Dysplasia, which can have lifelong effects on breathing and lung health. At the moment there are no treatments available that can slow down the progress of these diseases or prevent them.
We need to take a bold, new approach to identify novel treatments for these diseases; this is the aim of our research.
Regenerative medicine for lungs
Regenerative biology now offers real potential to repair or regrow damaged lungs and we are working at the forefront of this exciting field. Our research aims to transform our understanding of alveolar biology and accelerate the discovery of new regenerative medicine treatments.
Lung slices- ‘mini-lungs’ for discovery and drug screening
Many of our research projects use lung slices (also known as precision-cut lung slices, PCLS) to investigate mechanisms of lung injury and repair. These lung slices are in effect ‘mini-lungs’ as they consist of 3-D lung tissue pieces, containing all resident lung cell types in their natural arrangements and ratios.
To find out about current research opportunities in the lab please contact:
Dr Charlotte Dean (c.dean@imperial.ac.uk)
To find out more or contribute to our program please contact:
Dr Matthew Hind (m.hind@rbht.nhs.uk) or
Dr Charlotte Dean (c.dean@imperial.ac.uk)
If you are interested in learning about or using the models we have developed for research or drug screening purposes please email us or see Model for Lung Repair
Address: Room 363 Sir Alexander Fleming Building, National Heart and Lung Institute, South Kensington Campus, Imperial College London, Exhibition Road, London SW7 2AZ
